Antimicrobial peptides (AMPs), an important part of the innate immune system of different organisms, composed of 20-60 amino acid residues with positive charge, plays an important role in intestinal mucosal system. Learn more
Because the current intensive farming has artificially interfered with the natural growth of animals, resulting in a series of fundamental problems, such as mucosal immunity suppression, intestinal morphology injury, intestinal renewall disordal, and etc. Homologous bioactive substances can help to solve these problems, AMP is one kind.
Especially Defensin, is one kind of AMPs. It has evolved over a long period of time in an organism's struggle with disease. As an innate immune effector molecule, it provides the first effective defense against pathogen infection. Defensin can not only directly resist pathogenic microorganisms, but also have immunomodulatory effects. Learn more
The Guardian of the First Defense Line of Animals
It is the earlier immune way of defense means than the lymphocytes and immune globulin, and is an effective defense way due to the vertebrate animal long-term evolution.
AMPs in intestinal mucosa plays an important role. On the one hand,when pathogens invade the organism the AMPs will stimulate the body to produce innate immune response; on the other hand the AMPs will prevent excessive inflammation to protect the body from harm.
Defensins enhance the activity and chemotaxis of non-specific immune cells,especially macrophages, through cell signaling. Defensins can also promote the chemotaxis and proliferation of T cells, enhance the immune response ability of the body, regulate specific immunity, and enhance the active defense function of the body.
Best Choice of the Pro-Antibiotic Era
The anti-microbial resistance of microorganisms is becoming
increasingly serious with the abuse of antibiotics in agriculture
and animal husbandry, especially in developing countries.
A healthy intestinal system should be a balanced homoestasis. In the post-antibiotic era, the harm caused by harmful bacteria is dealt with by allowing good bacteria to compete with bad bacteria, rather than allowing antibiotics to kill all the bacteria. In this way, the imbalance of the flora, the proliferation of resistant strains, and the adverse reactions of drugs caused by the use of antibiotics are overcome.
AMPs, a potent alternative to antibiotics, achieve broad-spectrum antibacterial effect through physical action caused by the perforation of cell membrane. Meanwhile, a combination of antibiotics with β-Defensin can lead an increase in antibacterial activity.